Wedge biopsy can be performed with which instruments?

• A. Endoscope and laser
• B. Scalpel, scissors, or staple device
• C. Needle biopsy gun
• D. Fine cannula

Answer: (B)

Wedge biopsy during laparoscopy relies on instruments that can precisely cut out a wedge-shaped piece of tissue and control bleeding. A scalpel or scissors are ideal for making clean, controlled cuts to shape and remove the sample. A stapler device can also be used to transect the tissue and simultaneously seal the margins, providing rapid hemostasis and a clean specimen. Other options aren’t suited for this purpose: a needle biopsy gun is meant for small core samples obtained percutaneously, not a wedge taken inside the abdomen; a fine cannula is generally for aspiration or injection rather than tissue excision; and endoscope with laser isn’t the standard method for obtaining a wedge sample because laser use can cause thermal damage and the endoscope’s role is primarily visualization.